{
  "object_id": "revive:losartan-100mg",
  "object_type": "Dose Decision Object",
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  "language": "en",
  "canonical_url": "/losartan-100mg/",
  "canonical_page_h1": "Losartan 100mg: Dose Decision Guide",
  "entity_slug": "losartan-100mg",
  "primary_entity": "losartan",
  "entity_family": "ARBs",
  "page_kind": "dose",
  "decision_stage": "BOFU / decision",
  "ymyl": true,
  "source_phase": "Phase 2 Answer-First Citation Blocks",
  "decision_dimensions": [
    "dose_role",
    "effectiveness",
    "response",
    "tolerability",
    "escalation",
    "deescalation",
    "monitoring",
    "interactions",
    "comorbidity",
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    "safety",
    "patient_context",
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  ],
  "answers": [
    {
      "query_id": "RZQ-01465",
      "question": "What does losartan 100 mg mean in the drug's overall dosing range?",
      "short_answer": "Losartan and another ARB can have very different dose ranges. A 50 mg tablet of one drug is not meaningfully compared with an 80 mg or 160 mg tablet of another on number alone. Indication, response, tolerability, and evidence for the clinical setting matter far more.",
      "citations": [
        {
          "label": "MedlinePlus drug information: Losartan",
          "url": "https://medlineplus.gov/druginfo/meds/a695008.html"
        },
        {
          "label": "DailyMed current human drug-label search: Losartan",
          "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=human&query=losartan"
        },
        {
          "label": "NHS medicine information: Losartan",
          "url": "https://www.nhs.uk/medicines/losartan/"
        }
      ]
    },
    {
      "query_id": "RZQ-01466",
      "question": "Why might losartan 100 mg be chosen instead of a lower or higher strength?",
      "short_answer": "Losartan 100 mg is the upper sibling strength in this set, with 50 mg below it. This page therefore emphasizes whether the additional exposure is justified and whether the intended goal was already achieved at a lower strength. Compare Losartan 100mg: Dose Decision Guide by approved use, dosing context, clinical safety, interactions, monitoring, treatment expense factors and practical treatment decisions.",
      "citations": [
        {
          "label": "MedlinePlus drug information: Losartan",
          "url": "https://medlineplus.gov/druginfo/meds/a695008.html"
        },
        {
          "label": "DailyMed current human drug-label search: Losartan",
          "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=human&query=losartan"
        },
        {
          "label": "NHS medicine information: Losartan",
          "url": "https://www.nhs.uk/medicines/losartan/"
        }
      ]
    },
    {
      "query_id": "RZQ-01467",
      "question": "Is losartan 100 mg usually a starting, middle, or upper-range dose decision?",
      "short_answer": "Compare Losartan 100mg: Dose Decision Guide by approved use, dosing context, clinical safety, interactions, monitoring, treatment expense factors and practical treatment decisions. Losartan and another ARB can have very different dose ranges. A 50 mg tablet of one drug is not meaningfully compared with an 80 mg or 160 mg tablet of another on number alone.",
      "citations": [
        {
          "label": "MedlinePlus drug information: Losartan",
          "url": "https://medlineplus.gov/druginfo/meds/a695008.html"
        },
        {
          "label": "DailyMed current human drug-label search: Losartan",
          "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=human&query=losartan"
        },
        {
          "label": "NHS medicine information: Losartan",
          "url": "https://www.nhs.uk/medicines/losartan/"
        }
      ]
    }
  ],
  "related_questions": [
    {
      "query_id": "RZQ-01465",
      "question": "What does losartan 100 mg mean in the drug's overall dosing range?",
      "priority": "P1",
      "micro_intent": "dose_role"
    },
    {
      "query_id": "RZQ-01466",
      "question": "Why might losartan 100 mg be chosen instead of a lower or higher strength?",
      "priority": "P1",
      "micro_intent": "dose_role"
    },
    {
      "query_id": "RZQ-01467",
      "question": "Is losartan 100 mg usually a starting, middle, or upper-range dose decision?",
      "priority": "P1",
      "micro_intent": "dose_role"
    },
    {
      "query_id": "RZQ-01468",
      "question": "What should someone expect to evaluate after using losartan 100 mg?",
      "priority": "P2",
      "micro_intent": "effectiveness"
    },
    {
      "query_id": "RZQ-01469",
      "question": "If losartan 100 mg is not working well enough, does that automatically mean the dose should be increased?",
      "priority": "P2",
      "micro_intent": "response"
    },
    {
      "query_id": "RZQ-01470",
      "question": "How can someone tell whether losartan 100 mg is doing what it is supposed to do?",
      "priority": "P2",
      "micro_intent": "response"
    },
    {
      "query_id": "RZQ-01471",
      "question": "What side effects would make losartan 100 mg worth reviewing?",
      "priority": "P2",
      "micro_intent": "tolerability"
    },
    {
      "query_id": "RZQ-01472",
      "question": "When can a lower dose than losartan 100 mg become a reasonable discussion?",
      "priority": "P2",
      "micro_intent": "tolerability"
    },
    {
      "query_id": "RZQ-01473",
      "question": "What evidence would justify moving above losartan 100 mg?",
      "priority": "P2",
      "micro_intent": "escalation"
    },
    {
      "query_id": "RZQ-01474",
      "question": "What evidence would justify stepping down from losartan 100 mg?",
      "priority": "P2",
      "micro_intent": "deescalation"
    },
    {
      "query_id": "RZQ-01475",
      "question": "What monitoring matters after starting or changing to losartan 100 mg?",
      "priority": "P2",
      "micro_intent": "monitoring"
    },
    {
      "query_id": "RZQ-01476",
      "question": "Can other medicines change how losartan 100 mg should be evaluated?",
      "priority": "P2",
      "micro_intent": "interactions"
    },
    {
      "query_id": "RZQ-01477",
      "question": "How can kidney, liver, heart, or vascular conditions affect the decision around losartan 100 mg?",
      "priority": "P2",
      "micro_intent": "comorbidity"
    },
    {
      "query_id": "RZQ-01478",
      "question": "Could timing or missed doses make losartan 100 mg look ineffective?",
      "priority": "P2",
      "micro_intent": "adherence"
    },
    {
      "query_id": "RZQ-01479",
      "question": "When should someone consider changing the drug instead of changing losartan 100 mg?",
      "priority": "P2",
      "micro_intent": "switching"
    },
    {
      "query_id": "RZQ-01480",
      "question": "How is losartan 100 mg different from the nearest lower strength?",
      "priority": "P2",
      "micro_intent": "comparison"
    },
    {
      "query_id": "RZQ-01481",
      "question": "How is losartan 100 mg different from the nearest higher strength?",
      "priority": "P2",
      "micro_intent": "comparison"
    },
    {
      "query_id": "RZQ-01482",
      "question": "What are the main safety questions to ask before changing losartan 100 mg?",
      "priority": "P2",
      "micro_intent": "safety"
    },
    {
      "query_id": "RZQ-01483",
      "question": "What if losartan 100 mg works but causes side effects?",
      "priority": "P2",
      "micro_intent": "patient_context"
    },
    {
      "query_id": "RZQ-01484",
      "question": "What if losartan 100 mg is tolerated but the treatment goal is not reached?",
      "priority": "P2",
      "micro_intent": "patient_context"
    },
    {
      "query_id": "RZQ-01485",
      "question": "I am taking losartan 100 mg. What should I track before asking for a dose change?",
      "priority": "P2",
      "micro_intent": "natural_language"
    },
    {
      "query_id": "RZQ-01486",
      "question": "My doctor mentioned losartan 100 mg. What questions should I ask before changing doses?",
      "priority": "P2",
      "micro_intent": "natural_language"
    },
    {
      "query_id": "RZQ-01487",
      "question": "How do I know whether the problem is the dose or the medication itself with losartan 100 mg?",
      "priority": "P2",
      "micro_intent": "natural_language"
    },
    {
      "query_id": "RZQ-01488",
      "question": "What is the most important decision logic around losartan 100 mg?",
      "priority": "P2",
      "micro_intent": "summary"
    }
  ],
  "evidence": [
    {
      "label": "MedlinePlus drug information: Losartan",
      "url": "https://medlineplus.gov/druginfo/meds/a695008.html"
    },
    {
      "label": "DailyMed current human drug-label search: Losartan",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=human&query=losartan"
    },
    {
      "label": "NHS medicine information: Losartan",
      "url": "https://www.nhs.uk/medicines/losartan/"
    }
  ],
  "review": {
    "visible_page_review_date": null,
    "object_generated_date": "2026-09-11",
    "claim_level_confidence": "not_assigned",
    "confidence_note": "This object preserves answer text and citations already present on the canonical page. Claim-level confidence scoring and source-provenance grading are deferred to the later evidence/provenance phase."
  },
  "safety": {
    "educational_only": true,
    "not_individual_prescribing_advice": true,
    "do_not_stop_or_change_prescription_without_clinician_review": true
  },
  "implementation": {
    "preferred_rendering": "answer-first blocks + machine-readable JSON",
    "new_url_required": false,
    "canonical_page_remains_primary": true
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}